NuMat Medtech
NuMat Medtech is focusing on 2 bioactive coatings, based on small molecules of natural origin with potential applications in dental and orthopedic markets. The coatings have been developed by NuMat Medtech trying to address the main challenges of the current commercial medical implants, including poor osteointegration and high risk of infection.
NM_977
Bioactive surface modified with phytate for improving bone integration with antimicrobial effect and anti-inflammatory response.
Phytate is a natural molecule abundant in plant seeds and grains that acts as an inhibitor of bone resorption. It is adsorbed on the surface of hydroxyapatite crystals, the mineral constituent of the bone matrix, inhibiting its dissolution and decreasing the progressive loss of bone mass in osteoporotic animal models.
Metallic surfaces coated with phytate show osteogenic and anti-inflammatory properties and a decrease in bacterial adhesion.
Osseointegration properties
Anti-inflammatory effect
Reduced Bacterial colonization
Bioactive surface modified with phytate
Publications
Córdoba, A.; et al. (2016). Direct Covalent Grafting of Phytate to Titanium Surfaces through Ti–O–P Bonding Shows Bone Stimulating Surface Properties and Decreased Bacterial Adhesion. ACS Applied Materials & Interfaces 8 (18): 11326-11335.
Arriero, M. M.; et al. (2012). Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts. Plos One 7 (8): e43187
Arriero, M. M.; et al. (2012). Differential response of MC3T3-E1 and human mesenchymal stem cells to inositol hexakisphosphate. Cellular Physiology and Biochemistry 30 (4): 974-986